Abstract
Embolization of cerebral arteriovenous malformations (AVMs) has become an acceptable adjunct to surgery and radiosurgery. However, the kinetics of embolization using liquid polymers such as n-butyl 2-cyanoacrilate (NBCA) are not well understood. It is important to elucidate the kinetics of the gluing process in order to obtain a complete obliteration of the AVM, thus, preventing regrowth or need for further treatment. To study the kinetics of embolization we surgically constructed a model of an AVM by altering flow through the swine rete [Massoud et al., 1994, Murayama et al., 1998]. After a minimum of six months the rete was excised and connected to a perfusion loop for hemodynamic and embolization studies. Hemodynamic parameters such as pressure, flow, and glue injection pressure profiles were recorded. Various mixtures of lipiodol/isovue, were used to study flow velocity through the model. Glue/lipiodol/and glue/lipiodol/glacial acetic acid in several different combinations were injected to embolize the retia. All studies were recorded with high-speed digital subtraction angiography (DSA). After embolization and control angiography the retia were formaldehyde fixed for histological examination.
| Original language | English (US) |
|---|---|
| Title of host publication | American Society of Mechanical Engineers, Bioengineering Division (Publication) BED |
| Publisher | ASME |
| Pages | 651-652 |
| Number of pages | 2 |
| Volume | 42 |
| ISBN (Print) | 0791816117 |
| State | Published - Dec 1 1999 |
| Event | 1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999 |
Other
| Other | 1999 Bioengineering Conference |
|---|---|
| City | Big Sky, MT, USA |
| Period | 6/16/99 → 6/20/99 |