Kinetics of embolization in a chronic model of arteriovenous malformation in the swine

Baruch B. Lieber, Ajay K. Wakhloo, Joseph A. Wodenscheck, Matthew J. Gounis, Afshin A. Divani, Jason A. Kopko, Demetrius K. Lopes, Ryan N. Bourne

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Embolization of cerebral arteriovenous malformations (AVMs) has become an acceptable adjunct to surgery and radiosurgery. However, the kinetics of embolization using liquid polymers such as n-butyl 2-cyanoacrilate (NBCA) are not well understood. It is important to elucidate the kinetics of the gluing process in order to obtain a complete obliteration of the AVM, thus, preventing regrowth or need for further treatment. To study the kinetics of embolization we surgically constructed a model of an AVM by altering flow through the swine rete [Massoud et al., 1994, Murayama et al., 1998]. After a minimum of six months the rete was excised and connected to a perfusion loop for hemodynamic and embolization studies. Hemodynamic parameters such as pressure, flow, and glue injection pressure profiles were recorded. Various mixtures of lipiodol/isovue, were used to study flow velocity through the model. Glue/lipiodol/and glue/lipiodol/glacial acetic acid in several different combinations were injected to embolize the retia. All studies were recorded with high-speed digital subtraction angiography (DSA). After embolization and control angiography the retia were formaldehyde fixed for histological examination.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999


Other1999 Bioengineering Conference
CityBig Sky, MT, USA


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