Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists.

J. S. Marchant, I. Parker

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Elementary Ca2+ puffs form the basic building blocks of global Ins(1, 4,5)P3-evoked Ca2+ signals. In Xenopus oocytes, Ca2+ puffs evoked by the high-affinity agonist adenophostin were shorter and smaller than puffs evoked by Ins(1,4,5)P3 and the lower affinity analogue Ins(2,4, 5)P3. Agonist-specific mechanisms, therefore, play a role in shaping local Ca2+ release events, but termination of Ca2+ flux is not delimited simply by agonist dissociation.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalThe Biochemical journal
Volume334
Issue number3
DOIs
StatePublished - Sep 15 1998

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