Abstract
Elementary Ca2+ puffs form the basic building blocks of global Ins(1, 4,5)P3-evoked Ca2+ signals. In Xenopus oocytes, Ca2+ puffs evoked by the high-affinity agonist adenophostin were shorter and smaller than puffs evoked by Ins(1,4,5)P3 and the lower affinity analogue Ins(2,4, 5)P3. Agonist-specific mechanisms, therefore, play a role in shaping local Ca2+ release events, but termination of Ca2+ flux is not delimited simply by agonist dissociation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 505-509 |
| Number of pages | 5 |
| Journal | The Biochemical journal |
| Volume | 334 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 15 1998 |