TY - JOUR
T1 - Kinesins to the core
T2 - The role of microtubule-based motor proteins in building the mitotic spindle midzone
AU - Hornick, Jessica E.
AU - Karanjeet, Kul
AU - Collins, Elizabeth S.
AU - Hinchcliffe, Edward H
PY - 2010/5
Y1 - 2010/5
N2 - In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.
AB - In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.
KW - Cytokinesis
KW - Kinesin
KW - Microtubule
KW - Mitosis
KW - Motor protein
UR - http://www.scopus.com/inward/record.url?scp=77949492124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949492124&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2010.01.017
DO - 10.1016/j.semcdb.2010.01.017
M3 - Review article
C2 - 20109573
AN - SCOPUS:77949492124
VL - 21
SP - 290
EP - 299
JO - Seminars in cell & developmental biology
JF - Seminars in cell & developmental biology
SN - 1084-9521
IS - 3
ER -