Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

Melissa K. Gardner; David J. Odde; Kerry Bloom

doi:10.1016/j.tcb.2008.05.003

Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

Research output: Contribution to journal › Short survey › peer-review

Abstract

Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.

Original language	English (US)
Pages (from-to)	307-310
Number of pages	4
Journal	Trends in Cell Biology
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/j.tcb.2008.05.003
State	Published - Jul 2008

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10.1016/j.tcb.2008.05.003

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title = "Kinesin-8 molecular motors: putting the brakes on chromosome oscillations",

abstract = "Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.",

author = "Gardner, \{Melissa K.\} and Odde, \{David J.\} and Kerry Bloom",

year = "2008",

month = jul,

doi = "10.1016/j.tcb.2008.05.003",

language = "English (US)",

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pages = "307--310",

journal = "Trends in Cell Biology",

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T1 - Kinesin-8 molecular motors

T2 - putting the brakes on chromosome oscillations

AU - Gardner, Melissa K.

AU - Odde, David J.

AU - Bloom, Kerry

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Y1 - 2008/7

N2 - Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.

AB - Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.

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UR - https://www.scopus.com/pages/publications/46049112667#tab=citedBy

U2 - 10.1016/j.tcb.2008.05.003

DO - 10.1016/j.tcb.2008.05.003

M3 - Short survey

C2 - 18513970

AN - SCOPUS:46049112667

SN - 0962-8924

VL - 18

SP - 307

EP - 310

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 7

ER -

Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

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