Killing the second messenger: Targeting loss of cell cycle control in endocrine-resistant breast cancer

Keyphrases

• Retinoblastoma 100%
• Breast Cancer 100%
• Cell Cycle Control 100%
• Endocrine Therapy 100%
• Second Messenger 100%
• Cyclin-dependent Protein Kinases 100%
• Endocrine-resistant Breast Cancer 100%
• Estrogen Receptor 66%
• Cyclin D1 (CCND1) 66%
• Steroid Receptors 66%
• Exemestane 33%
• Fulvestrant 33%
• Ablation 33%
• Cell Cycle Regulation 33%
• Phosphorylation 33%
• Breast Cancer Progression 33%
• Acquired Resistance 33%
• Letrozole 33%
• PD0332991 33%
• Hormone Receptor-positive 33%
• Aromatase Inhibitors 33%
• Therapy-resistant 33%
• Cell Cycle Progression 33%
• Resistance Mechanisms 33%
• Cellular Senescence 33%
• Signal Transduction Pathway 33%
• B-type 33%
• Delayed Diagnosis 33%
• Clinical Intervention 33%
• Anastrozole 33%
• Growth Arrest 33%
• Multiple Signaling Pathways 33%
• Cell Line Models 33%
• Convergence Point 33%
• Breast Cancer Cell Lines 33%
• Poor Response 33%
• Unique Genes 33%
• Estrogen Synthesis 33%
• Regulatory Subunit 33%
• Cell Cycle Checkpoint Control 33%
• Luminal B 33%
• Cytostatic Agents 33%
• Ovarian Suppression 33%
• Resistance to Endocrine Therapy 33%
• Multiple Breast Cancer 33%
• Resistant Breast Cancer 33%
• Toremifene 33%
• Endocrine Resistance 33%
• Gene Signature 33%

Biochemistry, Genetics and Molecular Biology

• Second Messenger System 100%
• Cell Cycle Regulation 100%
• Cyclin-Dependent Kinase 100%
• Retinoblastoma 100%
• Signal Transduction 66%
• Estrogen Receptor 66%
• Cyclin D1 66%
• Steroid Hormone Receptor 66%
• Gene Signature 33%
• Cancer Cell 33%
• Upregulation 33%
• Mediator 33%
• Cell Cycle Progression 33%
• Cell Cycle Checkpoint 33%
• Hope 33%
• Estrogen Synthesis 33%
• Aromatase Inhibitor 33%
• Fulvestrant 33%
• Letrozole 33%
• Anastrozole 33%
• Exemestane 33%

Medicine and Dentistry

• Breast Cancer 100%
• Cell Cycle Regulation 100%
• Second Messenger 100%
• Hormone Therapy 57%
• Retinoblastoma 42%
• Cyclin-Dependent Kinase 42%
• Cyclin D1 28%
• Steroid Receptor 28%
• Estrogen Receptor 28%
• Mediator 14%
• Cancer Growth 14%
• Growth Disorder 14%
• Aromatase Inhibitor 14%
• Hope 14%
• Upregulation 14%
• Cell Cycle Progression 14%
• Signal Transduction Pathway 14%
• Fulvestrant 14%
• Cell Cycle Checkpoint 14%
• Breast Cancer Cell Line 14%
• Clinical Intervention 14%
• Cytostatic Agent 14%
• Estrogen Synthesis 14%
• Cellular Senescence 14%
• Toremifene 14%
• Tamoxifen 14%
• Signal Transduction 14%
• Exemestane 14%
• Letrozole 14%
• Anastrozole 14%