Kidneys and commonly used medications: how to reduce a risk of acute kidney injury in everyday practice?

Research output: Contribution to journalReview articlepeer-review

Abstract

Medications are a common cause of acute kidney injury (AKI). There are various mechanisms in which medications can induce AKI, and better understanding of their pathophysiology can aid in clinical recognition, treatment, and prevention of this condition. Hemodynamic-mediated AKI is often associated with drugs that alter renal perfusion and its autoregulation. Acute tubular injury is a result of direct renal tubular cell toxicity. Acute interstitial nephritis is a T-cell- mediated immune hypersensitivity reaction to drugs leading to tubule-interstitial inflammation and AKI. Crystalline nephropathy can be caused by crystallization of medications or by altered urinary chemistry caused by medications. Some medications can evoke AKI through uncommon mechanisms, such as glomerulonephritis and thrombotic microangiopathy. Notably, some medications may cause a phenomenon called "pseudo-AKI,"where serum creatinine is elevated without actual reduction in kidney function. Medications commonly used in clinical practice are reviewed with a focus on their mechanisms of injury, diagnosis, treatment, and prevention. Recognizing common medications associated with AKI is an important first step in reducing the risk of this condition. For each medication, understanding general and specific risk factors for AKI allows for early identification and timely discontinuation of offending agents. These measures can help mitigate the risk of AKI and promote renal recovery.

Original languageEnglish (US)
Article number16680
JournalPolish Archives of Internal Medicine
Volume134
Issue number9
DOIs
StatePublished - Sep 27 2024

Bibliographical note

Publisher Copyright:
© the Author(s), 2024.

Keywords

  • acute interstitial nephritis
  • acute kidney injury
  • acute tubular injury
  • crystalline nephropathy
  • drug-induced kidney injury

PubMed: MeSH publication types

  • Journal Article
  • Review

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