Kidney transplant donor glomerular filtration rate by iohexol clearance during computerized tomographic angiography of the kidneys

S. L. Hu, M. Igari, N. L. Walle, Michael W Steffes, M. D. Beland, S. A. Collins, R. Y. Gohh

Research output: Contribution to journalArticle

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Abstract

Background Pre-transplantation living-donor kidney function determines remaining donor kidney function and significantly affects post-transplantation allograft function in the recipient. Few transplantation centers perform donor kidney function measurement owing to patient burden. A simplified method of glomerular filtration rate (GFR) measurement after angiographic procedures may facilitate more precise measurement of donor kidney function. Methods We evaluated the agreement between a simplified method of GFR measurement after renal computerized tomographic (CT) angiography (index GFR, 100 mL iohexol [350 mg/mL iodine]) and the reference GFR measurement with the use of iodinated radiocontrast media (5 mL bolus of iohexol [300 mg/mL iodine]) among 19 potential living kidney transplant donors. The 24-hour creatinine clearance and GFR estimation equations were additionally examined. Kidney lengths and total and segmented cortical kidney volumes were also measured. Results The index CT angiography GFR performed best with respect to the reference GFR with minimal bias (mean difference, -4 mL/min/1.73 m2), good precision (SD of the difference, 9.8 mL/min/1.73 m2), coefficient of determination (R 2) of 0.74, narrow mean coefficient of variation (5% [range 1%-15%]), and high accuracy, with 100% of the values for the index test within 30% of the reference test. The 24-hour urine creatinine clearance values performed poorly. Kidney volumes and length did not significantly correlate with measured GFR. Conclusions The CT angiographic GFR measurement could be a useful and more convenient method of donor kidney function evaluation and maintains minimal bias, high precision, and accuracy compared with the reference GFR measurement.

Original languageEnglish (US)
Pages (from-to)3229-3233
Number of pages5
JournalTransplantation Proceedings
Volume45
Issue number9
DOIs
StatePublished - Nov 1 2013

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Iohexol
Glomerular Filtration Rate
Angiography
Tissue Donors
Kidney
Transplantation
Iodine
Creatinine
Living Donors
Contrast Media
Allografts
Urine

Cite this

Kidney transplant donor glomerular filtration rate by iohexol clearance during computerized tomographic angiography of the kidneys. / Hu, S. L.; Igari, M.; Walle, N. L.; Steffes, Michael W; Beland, M. D.; Collins, S. A.; Gohh, R. Y.

In: Transplantation Proceedings, Vol. 45, No. 9, 01.11.2013, p. 3229-3233.

Research output: Contribution to journalArticle

Hu, S. L. ; Igari, M. ; Walle, N. L. ; Steffes, Michael W ; Beland, M. D. ; Collins, S. A. ; Gohh, R. Y. / Kidney transplant donor glomerular filtration rate by iohexol clearance during computerized tomographic angiography of the kidneys. In: Transplantation Proceedings. 2013 ; Vol. 45, No. 9. pp. 3229-3233.
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abstract = "Background Pre-transplantation living-donor kidney function determines remaining donor kidney function and significantly affects post-transplantation allograft function in the recipient. Few transplantation centers perform donor kidney function measurement owing to patient burden. A simplified method of glomerular filtration rate (GFR) measurement after angiographic procedures may facilitate more precise measurement of donor kidney function. Methods We evaluated the agreement between a simplified method of GFR measurement after renal computerized tomographic (CT) angiography (index GFR, 100 mL iohexol [350 mg/mL iodine]) and the reference GFR measurement with the use of iodinated radiocontrast media (5 mL bolus of iohexol [300 mg/mL iodine]) among 19 potential living kidney transplant donors. The 24-hour creatinine clearance and GFR estimation equations were additionally examined. Kidney lengths and total and segmented cortical kidney volumes were also measured. Results The index CT angiography GFR performed best with respect to the reference GFR with minimal bias (mean difference, -4 mL/min/1.73 m2), good precision (SD of the difference, 9.8 mL/min/1.73 m2), coefficient of determination (R 2) of 0.74, narrow mean coefficient of variation (5{\%} [range 1{\%}-15{\%}]), and high accuracy, with 100{\%} of the values for the index test within 30{\%} of the reference test. The 24-hour urine creatinine clearance values performed poorly. Kidney volumes and length did not significantly correlate with measured GFR. Conclusions The CT angiographic GFR measurement could be a useful and more convenient method of donor kidney function evaluation and maintains minimal bias, high precision, and accuracy compared with the reference GFR measurement.",
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AU - Igari, M.

AU - Walle, N. L.

AU - Steffes, Michael W

AU - Beland, M. D.

AU - Collins, S. A.

AU - Gohh, R. Y.

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N2 - Background Pre-transplantation living-donor kidney function determines remaining donor kidney function and significantly affects post-transplantation allograft function in the recipient. Few transplantation centers perform donor kidney function measurement owing to patient burden. A simplified method of glomerular filtration rate (GFR) measurement after angiographic procedures may facilitate more precise measurement of donor kidney function. Methods We evaluated the agreement between a simplified method of GFR measurement after renal computerized tomographic (CT) angiography (index GFR, 100 mL iohexol [350 mg/mL iodine]) and the reference GFR measurement with the use of iodinated radiocontrast media (5 mL bolus of iohexol [300 mg/mL iodine]) among 19 potential living kidney transplant donors. The 24-hour creatinine clearance and GFR estimation equations were additionally examined. Kidney lengths and total and segmented cortical kidney volumes were also measured. Results The index CT angiography GFR performed best with respect to the reference GFR with minimal bias (mean difference, -4 mL/min/1.73 m2), good precision (SD of the difference, 9.8 mL/min/1.73 m2), coefficient of determination (R 2) of 0.74, narrow mean coefficient of variation (5% [range 1%-15%]), and high accuracy, with 100% of the values for the index test within 30% of the reference test. The 24-hour urine creatinine clearance values performed poorly. Kidney volumes and length did not significantly correlate with measured GFR. Conclusions The CT angiographic GFR measurement could be a useful and more convenient method of donor kidney function evaluation and maintains minimal bias, high precision, and accuracy compared with the reference GFR measurement.

AB - Background Pre-transplantation living-donor kidney function determines remaining donor kidney function and significantly affects post-transplantation allograft function in the recipient. Few transplantation centers perform donor kidney function measurement owing to patient burden. A simplified method of glomerular filtration rate (GFR) measurement after angiographic procedures may facilitate more precise measurement of donor kidney function. Methods We evaluated the agreement between a simplified method of GFR measurement after renal computerized tomographic (CT) angiography (index GFR, 100 mL iohexol [350 mg/mL iodine]) and the reference GFR measurement with the use of iodinated radiocontrast media (5 mL bolus of iohexol [300 mg/mL iodine]) among 19 potential living kidney transplant donors. The 24-hour creatinine clearance and GFR estimation equations were additionally examined. Kidney lengths and total and segmented cortical kidney volumes were also measured. Results The index CT angiography GFR performed best with respect to the reference GFR with minimal bias (mean difference, -4 mL/min/1.73 m2), good precision (SD of the difference, 9.8 mL/min/1.73 m2), coefficient of determination (R 2) of 0.74, narrow mean coefficient of variation (5% [range 1%-15%]), and high accuracy, with 100% of the values for the index test within 30% of the reference test. The 24-hour urine creatinine clearance values performed poorly. Kidney volumes and length did not significantly correlate with measured GFR. Conclusions The CT angiographic GFR measurement could be a useful and more convenient method of donor kidney function evaluation and maintains minimal bias, high precision, and accuracy compared with the reference GFR measurement.

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