Abstract
Systemic vasculitides encompass a group of diseases that can affect different caliber vessels. Large-vessel vasculitides (giant cell arteritis and Takayasu arteritis) affect the kidney by predominantly affecting blood flow leading to renal ischemia and renovascular hypertension. Medium-vessel vasculitides (polyarteritis nodosa and Kawasaki disease) can reduce flow through the renal artery and may affect intrarenal arteries, resulting in infarction and hemorrhage. Small-vessel vasculitides (antineutrophil cytoplasmic antibody [ANCA] vasculitis, antiglomerular basement membrane [GBM] disease, immunoglobulin A [IgA] vasculitis, and cryoglobulinemic vasculitis) affect the glomerular capillaries resulting in glomerulonephritis. This chapter reviews the pathology, pathogenesis, clinical features, and management of each class of vasculitis with a primary focus on kidney involvement.
| Original language | English (US) |
|---|---|
| Title of host publication | National Kidney Foundation's Primer on Kidney Diseases |
| Publisher | Elsevier |
| Pages | 235-244.e2 |
| ISBN (Electronic) | 9780323477949 |
| ISBN (Print) | 9780323510608 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 by Elsevier, Inc., and National Kidney Foundation. All rights reserved.
Keywords
- ANCA vasculitis
- IgA vasculitis
- Kawasaki disease
- Takayasu arteritis
- anti-GBM disease
- giant cell arteritis
- granulomatosis with polyangiitis
- immune complex vasculitis
- large-vessel vasculitis
- medium-vessel vasculitis
- microscopic polyangiitis
- pauci-immune vasculitis
- polyarteritis nodosa
- small-vessel vasculitis
- systemic vasculitis