Kidney Injury Biomarkers in Leptospirosis

Pablo Uribe-Restrepo, Claudia Munoz-Zanzi, Piedad Agudelo-Flórez

Research output: Contribution to journalReview articlepeer-review


Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal infections, is the most frequent complication associated with leptospirosis. Novel biomarkers are being studied as tools for assessing kidney injury in different pathological processes to improve early detection. This review aimed to gather information on the use of novel kidney biomarkers for human leptospirosis. A search of the literature was carried out in September 2021 using the parameters “((kidney) OR (renal) OR (chronic kidney disease) OR (acute kidney injury)) AND ((biomarker) OR (marker)) AND ((Leptospira) OR (leptospirosis))”. The review identified 11 original studies that evaluated the performance of 15 kidney biomarkers related to leptospirosis. Assessment of the evidence for biomarker utility was limited because of the small number of studies and sample sizes. Although some biomarkers were associated with kidney disease, no specific biomarker appeared to be ready for clinical practice, and more research in this field is necessary.

Original languageEnglish (US)
Article numbere0260-2022
JournalRevista da Sociedade Brasileira de Medicina Tropical
StatePublished - 2023

Bibliographical note

Funding Information:
Financial Support: This review was done as part of a project funded by the Dirección de Investigación e Innovación of Universidad CES, Code INV.032022.002.

Publisher Copyright:
© 2023, Sociedade Brasileira de Medicina Tropical. All rights reserved.


  • Acute kidney injury
  • Biomarkers
  • Kidney disease
  • Leptospira
  • Leptospirosis


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