Kidney function and sarcopenia in the United States general population: NHANES III

Robert N. Foley, Changchun Wang, Areef Ishani, Allan J. Collins, Anne M. Murray

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


Background/Aims: It is not known whether sarcopenia is associated with levels of kidney function in community-dwelling adults. Methods: Subjects were adult Third National Health and Nutrition Examination Survey participants in whom bioimpedance was performed (n = 13,770). Class I sarcopenia was defined as a skeletal mass index of 1-2 standard deviations below and class II sarcopenia as <2 standard deviations below young adult values. Results: A monotonic association existed between increasing sarcopenia prevalence and declining glomerular filtration rate: ≥90 ml/min/1.73 m2, 22.8% class I, 3.8% class II sarcopenia; 60-89 ml/min/1.73 m2, 33.6% class I, 5.3% class II sarcopenia, and <60 ml/min/1.73 m2, 50.7% class I, 9.4% class II sarcopenia (p < 0.0001). This association dissipated when adjustment was made for older age and more comorbidity. Multivariate associations (p < 0.05) of sarcopenia and chronic kidney disease included: older age; low income-to-poverty ratio; overweight; lack of exercise; low carbohydrate, fat and protein intake; hypercalcemia; low 25-hydroxy-vitamin D3; higher diastolic blood pressure, and insulin resistance. Conclusion: Sarcopenia is common in community-dwelling adults with chronic kidney disease. Although causality cannot be assumed, several associations may be susceptible to intervention.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalAmerican Journal of Nephrology
Issue number3
StatePublished - May 2007


  • Chronic kidney disease
  • Glomerular filtration rate
  • Kidney function
  • Muscle mass
  • Sarcopenia


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