Kidney delayed graft function after combined kidney-solid organ transplantation: A review

Kurtis J. Swanson, Brenda Muth, Fahad Aziz, Neetika Garg, Maha Mohamed, Margaret Bloom, Didier Mandelbrot, Sandesh Parajuli

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Kidney delayed graft function (K-DGF) is a common post-kidney transplant complication associated with adverse outcomes. With continued advances in solid organ transplantation (SOT), combined kidney-solid organ transplantation (CKSOT) is an ever-growing transplant option for patients with advanced kidney disease in the setting of concurrent solid organ failure. K-DGF in this setting is understudied. In this review, we aimed to abridge the representative literature on K-DGF in CKSOT. K-DGF occurs at different rates across combined and sequential kidney-solid organ transplantation (SKSOT), in simultaneous-pancreas kidney (SPK) transplant (8–23%), simultaneous heart-kidney (SHK) transplant (27–37%), simultaneous-liver kidney (SLiK) transplant (16–49%), and kidney after thoracic (13.6–19.2%) and abdominal (13.6–25%) transplantation. Though many K-DGF risk factors span across various subtypes of combined KSOT, some effect particular transplant types more specifically and may be modifiable to reduce K-DGF incidence. While more studies are needed to prevent and manage K-DGF in combined kidney-solid organ transplantation, we hope our review will provide context of this disease and spur further inquiry.

Original languageEnglish (US)
Article number100707
JournalTransplantation Reviews
Issue number3
StatePublished - Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.


  • Combined kidney-solid organ transplantation
  • Delayed graft function
  • Graft survival
  • Kidney transplantation
  • Patient survival

PubMed: MeSH publication types

  • Journal Article
  • Review


Dive into the research topics of 'Kidney delayed graft function after combined kidney-solid organ transplantation: A review'. Together they form a unique fingerprint.

Cite this