Key concepts in glioblastoma therapy

Jiri Bartek, Kimberly Ng, Jiri Bartek, Walter Fischer, Bob Carter, Clark C. Chen

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Glioblastoma is the most common form of primary brain cancer and remains one of the most aggressive forms of human cancer. Current standard of care involves maximal surgical resection followed by concurrent therapy with radiation and the DNA alkylating agent temozolomide. Despite this aggressive regimen, the median survival remains approximately 14 months. Meaningful strategies for therapeutic intervention are desperately needed. Development of such strategies will require an understanding of the therapeutic concepts that have evolved over the past three decades. This article reviews the key principles that drive the formulation of therapeutic strategies in glioblastoma. Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed.

Original languageEnglish (US)
Pages (from-to)753-760
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume83
Issue number7
DOIs
StatePublished - Jul 1 2012

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Glioblastoma
temozolomide
Cellular Microenvironment
Tumor Microenvironment
Neoplastic Stem Cells
Alkylating Agents
Standard of Care
Oncogenes
Brain Neoplasms
DNA Damage
Neoplasms
Radiotherapy
Therapeutics
Survival
DNA

Cite this

Key concepts in glioblastoma therapy. / Bartek, Jiri; Ng, Kimberly; Bartek, Jiri; Fischer, Walter; Carter, Bob; Chen, Clark C.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 83, No. 7, 01.07.2012, p. 753-760.

Research output: Contribution to journalReview article

Bartek, J, Ng, K, Bartek, J, Fischer, W, Carter, B & Chen, CC 2012, 'Key concepts in glioblastoma therapy', Journal of Neurology, Neurosurgery and Psychiatry, vol. 83, no. 7, pp. 753-760. https://doi.org/10.1136/jnnp-2011-300709
Bartek, Jiri ; Ng, Kimberly ; Bartek, Jiri ; Fischer, Walter ; Carter, Bob ; Chen, Clark C. / Key concepts in glioblastoma therapy. In: Journal of Neurology, Neurosurgery and Psychiatry. 2012 ; Vol. 83, No. 7. pp. 753-760.
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