Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: Sex differences

Marilyn E Carroll, Una C. Campbell, Paul Heideman

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The effects of ketoconazole, an inhibitor of corticosterone synthesis, were examined during food satiation and food restriction in male and female rats to determine whether increases in heroin self-administration prompted by food restriction were due to a stress response. Females self-administered more heroin infusions than males under both feeding conditions. Food restriction increased heroin infusions by an average of 96% for both females and males. Ketoconazole suppressed the increase due to food restriction in females but not in males. Corticosterone reversed the effect of ketoconazole in a group of 8 females, suggesting an interaction between feeding conditions, sex, and the stress response in rats.

Original languageEnglish (US)
Pages (from-to)307-316
Number of pages10
JournalExperimental and Clinical Psychopharmacology
Volume9
Issue number3
DOIs
StatePublished - 2001

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