Keeping lung surfactant where it belongs: Protein regulation of two-dimensional viscosity

Coralie Alonso, Alan Waring, Joseph A. Zasadzinski

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Lung surfactant causes the surface tension, γ, in the alveoli to drop to nearly zero on exhalation; in the upper airways γ is ∼30 mN/m and constant. Hence, a surface tension gradient exists between alveoli and airways that should lead to surfactant flow out of the alveoli and elimination of the surface tension gradient. However, the lung surfactant specific protein SP-C enhances the resistance to surfactant flow by regulating the ratio of solid to fluid phase in the monolayer, leading to a jamming transition at which the monolayer transforms from fluidlike to solidlike. The accompanying three orders of magnitude increase in surface viscosity helps minimize surfactant flow to the airways and likely stabilizes the alveoli against collapse.

Original languageEnglish (US)
Pages (from-to)266-273
Number of pages8
JournalBiophysical journal
Volume89
Issue number1
DOIs
StatePublished - Jul 2005
Externally publishedYes

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