Keeping lung surfactant where it belongs

Joesph A. Zasadzinski

Keeping lung surfactant where it belongs

Chemical Engineering and Materials Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Lung surfactant causes the surface tension in the alveoli to drop to nearly zero on exhalation; in the upper airways the surface tension is about 30 mN/m and constant. Hence, a surface tension gradient exists between alveoli and airways that should lead to surfactant flow out of the alveoli and elimination of the surface tension gradient. However, the lung surfactant specific protein SP-C enhances the resistance to surfactant flow by altering the ratio of solid to fluid phase in the monolayer, leading to a jamming transition. The accompanying 3 orders of magnitude increase in surface viscosity minimizes surfactant flow to the airways, and likely stabilizes the alveoli against collapse.

Original language	English (US)
Title of host publication	05AIChE
Subtitle of host publication	2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings
Number of pages	1
State	Published - Dec 1 2005
Event	05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States Duration: Oct 30 2005 → Nov 4 2005

Other

Other	05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
Country/Territory	United States
City	Cincinnati, OH
Period	10/30/05 → 11/4/05

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title = "Keeping lung surfactant where it belongs",

abstract = "Lung surfactant causes the surface tension in the alveoli to drop to nearly zero on exhalation; in the upper airways the surface tension is about 30 mN/m and constant. Hence, a surface tension gradient exists between alveoli and airways that should lead to surfactant flow out of the alveoli and elimination of the surface tension gradient. However, the lung surfactant specific protein SP-C enhances the resistance to surfactant flow by altering the ratio of solid to fluid phase in the monolayer, leading to a jamming transition. The accompanying 3 orders of magnitude increase in surface viscosity minimizes surfactant flow to the airways, and likely stabilizes the alveoli against collapse.",

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year = "2005",

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AU - Zasadzinski, Joesph A.

PY - 2005/12/1

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N2 - Lung surfactant causes the surface tension in the alveoli to drop to nearly zero on exhalation; in the upper airways the surface tension is about 30 mN/m and constant. Hence, a surface tension gradient exists between alveoli and airways that should lead to surfactant flow out of the alveoli and elimination of the surface tension gradient. However, the lung surfactant specific protein SP-C enhances the resistance to surfactant flow by altering the ratio of solid to fluid phase in the monolayer, leading to a jamming transition. The accompanying 3 orders of magnitude increase in surface viscosity minimizes surfactant flow to the airways, and likely stabilizes the alveoli against collapse.

AB - Lung surfactant causes the surface tension in the alveoli to drop to nearly zero on exhalation; in the upper airways the surface tension is about 30 mN/m and constant. Hence, a surface tension gradient exists between alveoli and airways that should lead to surfactant flow out of the alveoli and elimination of the surface tension gradient. However, the lung surfactant specific protein SP-C enhances the resistance to surfactant flow by altering the ratio of solid to fluid phase in the monolayer, leading to a jamming transition. The accompanying 3 orders of magnitude increase in surface viscosity minimizes surfactant flow to the airways, and likely stabilizes the alveoli against collapse.

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M3 - Conference contribution

AN - SCOPUS:33645573821

BT - 05AIChE

T2 - 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase

Y2 - 30 October 2005 through 4 November 2005

ER -

Keeping lung surfactant where it belongs

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