KCNJ10 (kir4.1) potassium channel knockout abolishes endocochlear potential

Daniel C. Marcus, Tao Wu, Philine Wangemann, Paulo Kofuji

Research output: Contribution to journalArticlepeer-review

232 Scopus citations

Abstract

Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the KCNJ10 (Kir4.1) K+ channel in strial intermediate cells did not generate an endocochlear potential. Endolymph volume and K+ concentration ([K+]) were reduced. These studies establish that the KCNJ10 K+ channel provides the molecular mechanism for generation of the endocochlear potential in concert with other transport pathways that establish the [K+] difference across the channel. KCNJ10 is also a limiting pathway for K+ secretion.

Original languageEnglish (US)
Pages (from-to)C403-C407
JournalAmerican Journal of Physiology - Cell Physiology
Volume282
Issue number2 51-2
DOIs
StatePublished - 2002

Keywords

  • Mouse
  • Null mutation
  • Potassium secretion
  • Stria vascularis
  • Transepithelial potential

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