Kasabach-Merritt syndrome

Sheilagh Maguiness, Lyn Guenther

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Background: Kasabach-Merritt syndrome (KMS) is a consumptive coagulopathy associated with the presence of a large vascular lesion. It is often a frustrating condition to treat and it carries a high mortality rate. There are currently no known treatment guidelines. Kasabach-Merritt syndrome is associated with kaposiform hemangioendothelioma (KHE) and tufted angioma (TA); these lesions, when associated with KMS, are locally invasive, aggressive vascular tumors. Treatment options include supportive care, local therapies, and drug and surgical management. In most recent case reports, a multimodal approach to therapy is taken. Objective and Conclusion: The objective of this article is to provide a comprehensive review of KMS and give an up-to-date summary of treatment options. The clinical presentation, laboratory findings, vascular pathology, and pathophysiology will also be discussed.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalJournal of Cutaneous Medicine and Surgery
Volume6
Issue number4
DOIs
StatePublished - Jul 1 2002

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