KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

Kyungjae Myung, Corey Braastad, Dong Ming He, Eric A. Hendrickson

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.

Original languageEnglish (US)
Pages (from-to)7664-7669
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number13
DOIs
StatePublished - Jun 23 1998

Bibliographical note

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

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