Kaposi's sarcoma in a cohort of homosexual and bisexual men

Alan R. Lifson, William W. Darrow, Nancy A. Hessol, Paul M. O'malley, J. Lowell Barnhart, Harold W. Jaffe, George W. Rutherford

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91 Scopus citations


Acquired immunodeficiency syndrome (AIDS) surveillance data for both the United States and San Francisco indicate that Kaposi's sarcoma is more common in homosexual and bisexual men with AIDS than in other adults with AIDS, and that the proportion of newly diagnosed AIDS cases presenting with Kaposi's sarcoma has been significantly declining over time. The changing epidemiology of Kaposl's sarcoma was analyzed in a well-characterized cohort of homosexual and bisexual men; laboratory and interview data from a sample of these men were evaluated for determinants of and cofactors associated with Kaposi's sarcoma. Among 1,341 men with AIDS, the proportion presenting with Kaposi's sarcoma declined from 79% in 1981 to 25% in 1989. Compared with other men with AIDS, men with Kaposi's sarcoma had a shorter interval from human immunodeficiency virus (HIV) seroconversion to AIDS diagnosis (median, 77 vs. 86 months). Men with and without Kapose's sarcoma did not significantly differ with respect to number of sexual partners, history of certain sexually transmitted or enteric diseases, use of certain recreational drugs (including nitrite inhalants), or participation in certain specific sexual practices. The decline in Kaposi's sarcoma may at least partly be due to a shorter latency period from infection to disease. Although cofactors for the development of Kaposi's sarcoma may exist, many previously hypothesized agents were not supported by this analysis.

Original languageEnglish (US)
Pages (from-to)221-231
Number of pages11
JournalAmerican journal of epidemiology
Issue number2
StatePublished - Feb 1990

Bibliographical note

Funding Information:
Robert Byers, Jack Campbell, Lyn Cannon, Lynda Doll, Joseph Engelman, Doug Franks, Michael Fngo, Janet Harrison, Scott Holmberg, Paul Jackson, Barbara Kilbourne, George Lemp, Rick Maus, Bobby Martin, Michael Piccini, Charles Schable, Eric Sorensen, Robert Wade, Judy Wilber, Tom Wilson, and Laune Windle. They also thank James Curran and Meade Morgan for their comments on the manuscript Supported by agreement # U62/CCU900523-03-5 from the Centers for Disease Control, Atlanta, GA

Copyright 2017 Elsevier B.V., All rights reserved.


  • Acquired immunodeficiency syndrome
  • HIV
  • Homosexuality
  • Sarcoma, Kaposi's


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