K103N mutation in antiretroviral therapy-naive african patients infected with HIV type 1

Omobosola Akinsete; Diane Hirigoyen; Charles Cartwright; Ron Schut; Rami Kantor; William K Henry

doi:10.1086/422519

K103N mutation in antiretroviral therapy-naive african patients infected with HIV type 1

Omobosola Akinsete
, Diane Hirigoyen
, Charles Cartwright
, Ron Schut
, Rami Kantor
, William K Henry

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.

Original language	English (US)
Pages (from-to)	575-578
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	39
Issue number	4
DOIs	https://doi.org/10.1086/422519
State	Published - Aug 15 2004

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AU - Hirigoyen, Diane

AU - Cartwright, Charles

AU - Schut, Ron

AU - Kantor, Rami

AU - Henry, William K

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AB - Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.

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K103N mutation in antiretroviral therapy-naive african patients infected with HIV type 1

Abstract

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