Junctions between cancer cells in culture: Ultrastructure and permeability

Ross G. Johnson, Judson D. Sheridan

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Cell junctions between Novikoff hepatoma cells (N1S1-67) growing as small clumps or chains in suspension culture have been studied with ultrastructural, electrophysiological, and dye-injection techniques. Cells within clumps are commonly electrically coupled and can exchange dyes with a molecular weight of 332 to 500. Gap junctions and intermediate junctions are present, whereas true tight junctions and desmosomes are absent or very rare. This system should provide a useful model for studying the properties of "communicating" junctions.

Original languageEnglish (US)
Pages (from-to)717-719
Number of pages3
Issue number4010
StatePublished - 1971


Dive into the research topics of 'Junctions between cancer cells in culture: Ultrastructure and permeability'. Together they form a unique fingerprint.

Cite this