Junctions between cancer cells in culture: Ultrastructure and permeability

Ross G. Johnson, Judson D. Sheridan

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Cell junctions between Novikoff hepatoma cells (N1S1-67) growing as small clumps or chains in suspension culture have been studied with ultrastructural, electrophysiological, and dye-injection techniques. Cells within clumps are commonly electrically coupled and can exchange dyes with a molecular weight of 332 to 500. Gap junctions and intermediate junctions are present, whereas true tight junctions and desmosomes are absent or very rare. This system should provide a useful model for studying the properties of "communicating" junctions.

Original languageEnglish (US)
Pages (from-to)717-719
Number of pages3
JournalScience
Volume174
Issue number4010
DOIs
StatePublished - Jan 1 1971

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