Abstract
Achromobacter xylosoxidans is associated with resilient nosocomial infections, with bacteraemia, pneumonia and chronic cystic fibrosis lung infection being the most common clinical presentations. Innate multi-drug resistance and a suite of virulence factors select for A. xylosoxidans infection during long-term antibiotic therapy, contributing to its persistence, treatment recalcitrance, association with poor clinical outcomes and emergence as a problematic pathogen. Horizontal gene transfer and maintenance of large genomes underpin the resilience and cosmopolitan lifestyle of A. xylosoxidans, and complicate its phylogenetic characterization.
| Original language | English (US) |
|---|---|
| Article number | 001505 |
| Journal | Journal of medical microbiology |
| Volume | 71 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2022 |
Bibliographical note
Funding Information:We acknowledge members of the Hunter laboratory for critical review of the manuscript.
Publisher Copyright:
© 2022 The Authors
Keywords
- multi-drug resistance
- opportunistic pathogen
- xylose
