JMM Profile: Achromobacter xylosoxidans: The cloak-and-dagger opportunist

Benjamin M Bonis, Ryan C. Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

Achromobacter xylosoxidans is associated with resilient nosocomial infections, with bacteraemia, pneumonia and chronic cystic fibrosis lung infection being the most common clinical presentations. Innate multi-drug resistance and a suite of virulence factors select for A. xylosoxidans infection during long-term antibiotic therapy, contributing to its persistence, treatment recalcitrance, association with poor clinical outcomes and emergence as a problematic pathogen. Horizontal gene transfer and maintenance of large genomes underpin the resilience and cosmopolitan lifestyle of A. xylosoxidans, and complicate its phylogenetic characterization.

Original languageEnglish (US)
Article number001505
JournalJournal of medical microbiology
Volume71
Issue number5
DOIs
StatePublished - 2022

Bibliographical note

Funding Information:
We acknowledge members of the Hunter laboratory for critical review of the manuscript.

Publisher Copyright:
© 2022 The Authors

Keywords

  • multi-drug resistance
  • opportunistic pathogen
  • xylose

PubMed: MeSH publication types

  • Journal Article

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