JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila

Stephanie Lerach, Weiguo Zhang, Huai Deng, Xiaomin Bao, Jack Girton, Jørgen Johansen, Kristen M. Johansen

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The upregulation of the JIL-1 kinase on the male X chromosome and its association with the male-specific lethal (MSL) complex suggest that JIL-1 may play a role in regulating dosage compensation. To directly test this hypothesis we measured eye pigment levels of mutants in the X-linked white gene in an allelic series of JIL-1 hypomorphic mutants. We show that dosage compensation of wa alleles that normally do exhibit dosage compensation was severely impaired in the JIL-1 mutant backgrounds. As a control we also examined a hypomorphic white allele we that fails to dosage compensate in males due to a pogo element insertion. In this case the relative pigment level measured in males as compared to females remained approximately the same even in the most severe JIL-1 hypomorphic background. These results indicate that proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalGenesis
Volume43
Issue number4
DOIs
StatePublished - Dec 2005

Keywords

  • Dosage compensation
  • Drosophila
  • Eye pigmentation
  • JIL-1 kinase
  • MSL complex

Fingerprint Dive into the research topics of 'JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila'. Together they form a unique fingerprint.

Cite this