Jak2/Stat5a/b pathway in prostate cancer

Marjha Nevalainen; Shilpa Gupta

doi:10.1007/978-1-4419-0717-2_52

Jak2/Stat5a/b pathway in prostate cancer

Marjha Nevalainen
, Shilpa Gupta

Medicine - Hematology, Oncology, Transplant

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Stat5a and Stat5b are two highly homologous proteins (94-kDa for Stat5a and 92-kDa for Stat5b), and their genes map to the human chromosome 17 (bands q11-1 to q22) (Lin et al., J Biol Chem 271:10738-10744, 1996). Besides Stat5a and Stat5b, there are five other members in the Stat family of transcription factors (Stat1, Stat2, Stat3, Stat4, and Stat6) which mediate diverse biological processes, including cell growth, differentiation, and survival. Stat5a was first discovered as a mammary gland factor (MGF) which mediates the effects of prolactin (Prl) in mice (Wakao et al., J Biol Chem 267:16365-16370, 1992). The Stat5b was encoded by a separate gene and was identified later in mouse mammary gland (Lin et al., J Biol Chem 271:10738-10744, 1996; Liu et al., Proc Natl Acad Sci U S A 92:8831-8835, 1995).

Original language	English (US)
Title of host publication	Cancer Therapeutic Targets
Publisher	Springer New York
Pages	745-752
Number of pages	8
Volume	2-2
ISBN (Electronic)	9781441907172
ISBN (Print)	9781441907165
DOIs	https://doi.org/10.1007/978-1-4419-0717-2_52
State	Published - Jan 1 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Androgen receptor
Functional domains in protein structure
High vs. low grade
Homo-/heterodimers
In prostate cancer
Jak2/Stat5a/b signaling pathway activation
Janus kinases
Mammary gland factor (MGF)
MgcRacGAP
MgcRacGAP
Preclinical studies
Prognostic marker
Signal transducer and activator of transcription 5a and 5b (Stat5a/b)
Therapeutics
Tyrosine residues Y694 and Y699

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10.1007/978-1-4419-0717-2_52

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title = "Jak2/Stat5a/b pathway in prostate cancer",

abstract = "Stat5a and Stat5b are two highly homologous proteins (94-kDa for Stat5a and 92-kDa for Stat5b), and their genes map to the human chromosome 17 (bands q11-1 to q22) (Lin et al., J Biol Chem 271:10738-10744, 1996). Besides Stat5a and Stat5b, there are five other members in the Stat family of transcription factors (Stat1, Stat2, Stat3, Stat4, and Stat6) which mediate diverse biological processes, including cell growth, differentiation, and survival. Stat5a was first discovered as a mammary gland factor (MGF) which mediates the effects of prolactin (Prl) in mice (Wakao et al., J Biol Chem 267:16365-16370, 1992). The Stat5b was encoded by a separate gene and was identified later in mouse mammary gland (Lin et al., J Biol Chem 271:10738-10744, 1996; Liu et al., Proc Natl Acad Sci U S A 92:8831-8835, 1995).",

keywords = "Androgen receptor, Functional domains in protein structure, High vs. low grade, Homo-/heterodimers, In prostate cancer, Jak2/Stat5a/b signaling pathway activation, Janus kinases, Mammary gland factor (MGF), MgcRacGAP, MgcRacGAP, Preclinical studies, Prognostic marker, Signal transducer and activator of transcription 5a and 5b (Stat5a/b), Therapeutics, Tyrosine residues Y694 and Y699",

author = "Marjha Nevalainen and Shilpa Gupta",

year = "2017",

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doi = "10.1007/978-1-4419-0717-2\_52",

language = "English (US)",

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AU - Nevalainen, Marjha

AU - Gupta, Shilpa

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N2 - Stat5a and Stat5b are two highly homologous proteins (94-kDa for Stat5a and 92-kDa for Stat5b), and their genes map to the human chromosome 17 (bands q11-1 to q22) (Lin et al., J Biol Chem 271:10738-10744, 1996). Besides Stat5a and Stat5b, there are five other members in the Stat family of transcription factors (Stat1, Stat2, Stat3, Stat4, and Stat6) which mediate diverse biological processes, including cell growth, differentiation, and survival. Stat5a was first discovered as a mammary gland factor (MGF) which mediates the effects of prolactin (Prl) in mice (Wakao et al., J Biol Chem 267:16365-16370, 1992). The Stat5b was encoded by a separate gene and was identified later in mouse mammary gland (Lin et al., J Biol Chem 271:10738-10744, 1996; Liu et al., Proc Natl Acad Sci U S A 92:8831-8835, 1995).

AB - Stat5a and Stat5b are two highly homologous proteins (94-kDa for Stat5a and 92-kDa for Stat5b), and their genes map to the human chromosome 17 (bands q11-1 to q22) (Lin et al., J Biol Chem 271:10738-10744, 1996). Besides Stat5a and Stat5b, there are five other members in the Stat family of transcription factors (Stat1, Stat2, Stat3, Stat4, and Stat6) which mediate diverse biological processes, including cell growth, differentiation, and survival. Stat5a was first discovered as a mammary gland factor (MGF) which mediates the effects of prolactin (Prl) in mice (Wakao et al., J Biol Chem 267:16365-16370, 1992). The Stat5b was encoded by a separate gene and was identified later in mouse mammary gland (Lin et al., J Biol Chem 271:10738-10744, 1996; Liu et al., Proc Natl Acad Sci U S A 92:8831-8835, 1995).

KW - Androgen receptor

KW - Functional domains in protein structure

KW - High vs. low grade

KW - Homo-/heterodimers

KW - In prostate cancer

KW - Jak2/Stat5a/b signaling pathway activation

KW - Janus kinases

KW - Mammary gland factor (MGF)

KW - MgcRacGAP

KW - Preclinical studies

KW - Prognostic marker

KW - Signal transducer and activator of transcription 5a and 5b (Stat5a/b)

KW - Therapeutics

KW - Tyrosine residues Y694 and Y699

UR - https://www.scopus.com/pages/publications/85038936110

UR - https://www.scopus.com/pages/publications/85038936110#tab=citedBy

U2 - 10.1007/978-1-4419-0717-2_52

DO - 10.1007/978-1-4419-0717-2_52

M3 - Chapter

AN - SCOPUS:85038936110

SN - 9781441907165

VL - 2-2

SP - 745

EP - 752

BT - Cancer Therapeutic Targets

PB - Springer New York

ER -

Jak2/Stat5a/b pathway in prostate cancer

Abstract

UN SDGs

Keywords

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