Jak2/Stat5a/b pathway in prostate cancer

Marjha Nevalainen, Shilpa Gupta

Research output: Chapter in Book/Report/Conference proceedingChapter


Stat5a and Stat5b are two highly homologous proteins (94-kDa for Stat5a and 92-kDa for Stat5b), and their genes map to the human chromosome 17 (bands q11-1 to q22) (Lin et al., J Biol Chem 271:10738-10744, 1996). Besides Stat5a and Stat5b, there are five other members in the Stat family of transcription factors (Stat1, Stat2, Stat3, Stat4, and Stat6) which mediate diverse biological processes, including cell growth, differentiation, and survival. Stat5a was first discovered as a mammary gland factor (MGF) which mediates the effects of prolactin (Prl) in mice (Wakao et al., J Biol Chem 267:16365-16370, 1992). The Stat5b was encoded by a separate gene and was identified later in mouse mammary gland (Lin et al., J Biol Chem 271:10738-10744, 1996; Liu et al., Proc Natl Acad Sci U S A 92:8831-8835, 1995).

Original languageEnglish (US)
Title of host publicationCancer Therapeutic Targets
PublisherSpringer New York
Number of pages8
ISBN (Electronic)9781441907172
ISBN (Print)9781441907165
StatePublished - Jan 1 2017


  • Androgen receptor
  • Functional domains in protein structure
  • High vs. low grade
  • Homo-/heterodimers
  • In prostate cancer
  • Jak2/Stat5a/b signaling pathway activation
  • Janus kinases
  • Mammary gland factor (MGF)
  • MgcRacGAP
  • MgcRacGAP
  • Preclinical studies
  • Prognostic marker
  • Signal transducer and activator of transcription 5a and 5b (Stat5a/b)
  • Therapeutics
  • Tyrosine residues Y694 and Y699


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