Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats

H. R. Moser; G. J. Giesler

doi:10.1016/j.neuroscience.2014.05.025

Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats

H. R. Moser, G. J. Giesler

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24 Scopus citations

Abstract

We used the cheek model of itch and pain in rats to determine the dose-response relationships for intradermal injection of serotonin and α methylserotonin on scratching behavior. We also determined the dose-related effects of intracisternally injected morphine on scratching, effects that were greatly reduced by administration of the opiate antagonist naloxone. We then examined the interactions of intradermal injection of serotonin and intracisternal injection of morphine on scratching and found that the two procedures act synergistically to increase itch. These results suggest that morphine applied to the CNS is capable of producing itch and greatly increasing itch originating in the skin (hyperknesis).

Original language	English (US)
Pages (from-to)	119-127
Number of pages	9
Journal	Neuroscience
Volume	274
DOIs	https://doi.org/10.1016/j.neuroscience.2014.05.025
State	Published - Aug 22 2014

Bibliographical note

Funding Information:
We thank H. Truong, B. Lipshetz and C. Hosfield for valuable technical assistance, N. Jansen and Drs. C.N. Honda, D.A. Simone and G.L. Wilcox for critically reading an early version of this manuscript. This work was supported by NIH grants P01 NS047399 , NINDS Core funding NS062158, and F31 NS077554 to HRM.

Keywords

Hyperknesis
Intracisternal injection
Itch
Morphine
Serotonin

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10.1016/j.neuroscience.2014.05.025

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title = "Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats",

abstract = "We used the cheek model of itch and pain in rats to determine the dose-response relationships for intradermal injection of serotonin and α methylserotonin on scratching behavior. We also determined the dose-related effects of intracisternally injected morphine on scratching, effects that were greatly reduced by administration of the opiate antagonist naloxone. We then examined the interactions of intradermal injection of serotonin and intracisternal injection of morphine on scratching and found that the two procedures act synergistically to increase itch. These results suggest that morphine applied to the CNS is capable of producing itch and greatly increasing itch originating in the skin (hyperknesis).",

keywords = "Hyperknesis, Intracisternal injection, Itch, Morphine, Serotonin",

author = "Moser, {H. R.} and Giesler, {G. J.}",

note = "Funding Information: We thank H. Truong, B. Lipshetz and C. Hosfield for valuable technical assistance, N. Jansen and Drs. C.N. Honda, D.A. Simone and G.L. Wilcox for critically reading an early version of this manuscript. This work was supported by NIH grants P01 NS047399 , NINDS Core funding NS062158, and F31 NS077554 to HRM. ",

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doi = "10.1016/j.neuroscience.2014.05.025",

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AU - Moser, H. R.

AU - Giesler, G. J.

N1 - Funding Information: We thank H. Truong, B. Lipshetz and C. Hosfield for valuable technical assistance, N. Jansen and Drs. C.N. Honda, D.A. Simone and G.L. Wilcox for critically reading an early version of this manuscript. This work was supported by NIH grants P01 NS047399 , NINDS Core funding NS062158, and F31 NS077554 to HRM.

PY - 2014/8/22

Y1 - 2014/8/22

N2 - We used the cheek model of itch and pain in rats to determine the dose-response relationships for intradermal injection of serotonin and α methylserotonin on scratching behavior. We also determined the dose-related effects of intracisternally injected morphine on scratching, effects that were greatly reduced by administration of the opiate antagonist naloxone. We then examined the interactions of intradermal injection of serotonin and intracisternal injection of morphine on scratching and found that the two procedures act synergistically to increase itch. These results suggest that morphine applied to the CNS is capable of producing itch and greatly increasing itch originating in the skin (hyperknesis).

AB - We used the cheek model of itch and pain in rats to determine the dose-response relationships for intradermal injection of serotonin and α methylserotonin on scratching behavior. We also determined the dose-related effects of intracisternally injected morphine on scratching, effects that were greatly reduced by administration of the opiate antagonist naloxone. We then examined the interactions of intradermal injection of serotonin and intracisternal injection of morphine on scratching and found that the two procedures act synergistically to increase itch. These results suggest that morphine applied to the CNS is capable of producing itch and greatly increasing itch originating in the skin (hyperknesis).

KW - Hyperknesis

KW - Intracisternal injection

KW - Itch

KW - Morphine

KW - Serotonin

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DO - 10.1016/j.neuroscience.2014.05.025

M3 - Article

C2 - 24875173

AN - SCOPUS:84902296688

SN - 0306-4522

VL - 274

SP - 119

EP - 127

JO - Neuroscience

JF - Neuroscience

ER -

Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats

Abstract

Bibliographical note

Keywords

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