Itch elicited by intradermal injection of serotonin, intracisternal injection of morphine, and their synergistic interactions in rats

H. R. Moser, G. J. Giesler

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We used the cheek model of itch and pain in rats to determine the dose-response relationships for intradermal injection of serotonin and α methylserotonin on scratching behavior. We also determined the dose-related effects of intracisternally injected morphine on scratching, effects that were greatly reduced by administration of the opiate antagonist naloxone. We then examined the interactions of intradermal injection of serotonin and intracisternal injection of morphine on scratching and found that the two procedures act synergistically to increase itch. These results suggest that morphine applied to the CNS is capable of producing itch and greatly increasing itch originating in the skin (hyperknesis).

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalNeuroscience
Volume274
DOIs
StatePublished - Aug 22 2014

Bibliographical note

Funding Information:
We thank H. Truong, B. Lipshetz and C. Hosfield for valuable technical assistance, N. Jansen and Drs. C.N. Honda, D.A. Simone and G.L. Wilcox for critically reading an early version of this manuscript. This work was supported by NIH grants P01 NS047399 , NINDS Core funding NS062158, and F31 NS077554 to HRM.

Keywords

  • Hyperknesis
  • Intracisternal injection
  • Itch
  • Morphine
  • Serotonin

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