Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling

Linlin Shang, Xinyu Weng, Dongzhi Wang, Wenhui Yue, Ray Mernaugh, Venkataraman Amarnath, E. Kenneth Weir, Samuel Dudley, Yawei Xu, Mingxiao Hou, Yingjie Chen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Increased levels of reactive isolevuglandins (IsoLGs) are associated with vascular inflammation and hypertension, two important factors affect heart failure (HF) development. The role of IsoLGs in HF development is unknown. Here we studied the role of IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) in transverse aortic constriction (TAC) induced heart failure. We observed that TAC caused a significant increase of IsoLG protein adducts in cardiac and lung tissues in mice. Both IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) and its less reactive isomer 4-hydroxybenzylamine (4-HOBA) significantly attenuated the left ventricular (LV) and lung IsoLGs in mice after TAC. 2-HOBA and 4-HOBA attenuated TAC-induced LV hypertrophy, heart failure, and the increase of lung weight in mice, and also improved TAC-induced LV dysfunction. Moreover, both 2-HOBA and 4-HOBA effectively attenuated LV cardiomyocyte hypertrophy, lung inflammation, lung fibrosis. These findings suggest that methods to reduce IsoLGs may be useful for HF therapy.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalFree Radical Biology and Medicine
Volume141
DOIs
StatePublished - Sep 2019

Bibliographical note

Funding Information:
This work was supported by research grants 81470512 and 81570355 from National Natural Science Foundation, and a grant in aid from American Heart Association, USA. None.

Funding Information:
This work was supported by research grants 81470512 and 81570355 from National Natural Science Foundation , and a grant in aid from American Heart Association, USA .

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • Cardiac hypertrophy
  • Fibrosis
  • Heart failure
  • Inflammation
  • Lung

Fingerprint

Dive into the research topics of 'Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling'. Together they form a unique fingerprint.

Cite this