Increased levels of reactive isolevuglandins (IsoLGs) are associated with vascular inflammation and hypertension, two important factors affect heart failure (HF) development. The role of IsoLGs in HF development is unknown. Here we studied the role of IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) in transverse aortic constriction (TAC) induced heart failure. We observed that TAC caused a significant increase of IsoLG protein adducts in cardiac and lung tissues in mice. Both IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) and its less reactive isomer 4-hydroxybenzylamine (4-HOBA) significantly attenuated the left ventricular (LV) and lung IsoLGs in mice after TAC. 2-HOBA and 4-HOBA attenuated TAC-induced LV hypertrophy, heart failure, and the increase of lung weight in mice, and also improved TAC-induced LV dysfunction. Moreover, both 2-HOBA and 4-HOBA effectively attenuated LV cardiomyocyte hypertrophy, lung inflammation, lung fibrosis. These findings suggest that methods to reduce IsoLGs may be useful for HF therapy.
|Original language||English (US)|
|Number of pages||8|
|Journal||Free Radical Biology and Medicine|
|State||Published - Sep 2019|
Bibliographical noteFunding Information:
This work was supported by research grants 81470512 and 81570355 from National Natural Science Foundation, and a grant in aid from American Heart Association, USA. None.
This work was supported by research grants 81470512 and 81570355 from National Natural Science Foundation , and a grant in aid from American Heart Association, USA .
© 2019 Elsevier Inc.
- Cardiac hypertrophy
- Heart failure