Isolectin IB4-mediated cytotoxic targeting of sensory neurons

Lucy Vulchanova, Christopher N. Honda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lectins are carbohydrate-binding proteins that recognize distinct oligosaccharide moieties of glycoproteins and glycolipids. In vertebrates, endogenous lectins serve a variety of functions, including cell adhesion, cell recognition, signal transduction, and endocytosis, in both neuronal and nonneuronal cells (1-5). A role for cell surface carbohydrate recognition has been described in processes, such as fertilization, development, leukocyte homing, and the innate immune response (1,2). Among the known classes of vertebrate carbohydrate-binding proteins are some cytokines (e.g., interleukin 1β [IL-1β]) and growth factors, which possess a receptor-binding domain and a carbohydrate recognition domain (4,5).

Original languageEnglish (US)
Title of host publicationMolecular Neurosurgery With Targeted Toxins
PublisherHumana Press
Pages265-291
Number of pages27
ISBN (Print)9781588291998
DOIs
StatePublished - Dec 1 2005

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