Isolation of a trimer of α-tocopherol from mammalian liver

H. H. Draper, A. S. Csallany, Mei Chiu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Evidence is presented for the formation in mammalian liver of a trimeric metabolite of α-tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of α-tocopherol with alkaline K3Fe(CN)6. In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl-p-quinone, are postulated to arise from reactions with lipid-free radicals or peroxides in the course of the antioxidant action of vitamin E.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
Issue number1
StatePublished - Jan 1967


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