Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

George R. Pettit, Qinghua Ye, Delbert L. Herald, John C. Knight, Fiona Hogan, Noeleen Melody, Venugopal J.R.V. Mukku, Dennis L. Doubek, Jean Charles Chapuis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1-4) were isolated, accompanied by four previously known triterpenes (5-8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1-8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.

Original languageEnglish (US)
Pages (from-to)1598-1603
Number of pages6
JournalJournal of Natural Products
Volume79
Issue number6
DOIs
StatePublished - Jun 24 2016
Externally publishedYes

Bibliographical note

Funding Information:
We are pleased to extend our thanks and appreciation for the financial support provided by grant R01 CA90441 from the Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, DHHS, and from the Arizona Biomedical Research Commission, Dr. Alec D. Keith, and the Robert B. Dalton Endowment Fund. We also appreciate the assistance provided by Dr. R. K. Pettit, as well as M. Dodson and C. A. Weber.

Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

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