Abstract
SYNOPSIS: The microsomal fraction prepared from canine myocardium was found to contain an active prostaglandin synthetase (average, 10 mμ mol PGE2/mg protein/min) which was capable of forming PGE2 from arachidonic acid in the presence of reduced glutathione and cofactors such as l-adrenaline, hydroquinone, and p-aminophenol. Neither aspirin nor phospholipase A, which have been reported to affect prostaglandin synthesis in other tissues, influences the activity of myocardial prostaglandin synthetase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 623-628 |
| Number of pages | 6 |
| Journal | Cardiovascular Research |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1973 |