Isolation and properties of myocardial prostaglandin synthetase

Constantinos J. Limas, Jay N. Cohn

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


SYNOPSIS: The microsomal fraction prepared from canine myocardium was found to contain an active prostaglandin synthetase (average, 10 mμ mol PGE2/mg protein/min) which was capable of forming PGE2 from arachidonic acid in the presence of reduced glutathione and cofactors such as l-adrenaline, hydroquinone, and p-aminophenol. Neither aspirin nor phospholipase A, which have been reported to affect prostaglandin synthesis in other tissues, influences the activity of myocardial prostaglandin synthetase.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalCardiovascular Research
Issue number5
StatePublished - 1973

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