Isolation and characterization of sclerienone c from scleria striatinux

Kennedy D. Nyongbela; Felix L. Makolo; Thomas R. Hoye; Simon M.N. Efange

doi:10.1177/1934578x1601100102

Isolation and characterization of sclerienone c from scleria striatinux

Kennedy D. Nyongbela, Felix L. Makolo, Thomas R. Hoye, Simon M.N. Efange

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Abstract

Herein, we report the isolation and characterization of sclerienone C, a novel sesquiterpene isolated from the methylene chloride/methanol (1:1) extract of Scleria striatinux that we have deduced to have structure 1. This medicinal spice of Cameroon has been shown to display antimicrobial and antiplasmodial activities. The isolation and purification involved a combination of methods including silica gel column chromatography, Sephadex LH-20, and semi-prep HPLC separations. Structure elucidation was carried-out by means of spectroscopic analysis and comparison with previously isolated sesquiterpene derivatives from the plant.

Original language	English (US)
Pages (from-to)	5-6
Number of pages	2
Journal	Natural Product Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1177/1934578x1601100102
State	Published - Jan 23 2016

Keywords

Antiplasmodial activity
Cyperaceae
Scleria striatinux
Sesquiterpene isomers

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Nyongbela, Kennedy D.

AU - Makolo, Felix L.

AU - Hoye, Thomas R.

AU - Efange, Simon M.N.

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AB - Herein, we report the isolation and characterization of sclerienone C, a novel sesquiterpene isolated from the methylene chloride/methanol (1:1) extract of Scleria striatinux that we have deduced to have structure 1. This medicinal spice of Cameroon has been shown to display antimicrobial and antiplasmodial activities. The isolation and purification involved a combination of methods including silica gel column chromatography, Sephadex LH-20, and semi-prep HPLC separations. Structure elucidation was carried-out by means of spectroscopic analysis and comparison with previously isolated sesquiterpene derivatives from the plant.

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KW - Sesquiterpene isomers

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Isolation and characterization of sclerienone c from scleria striatinux

Abstract

Keywords

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