Isolated tramadol overdose associated with brugada ECG pattern

Jon B. Cole; Srinivasan Sattiraju; Elisabeth F. Bilden; Richard W Asinger; Stefan C Bertog

doi:10.1111/j.1540-8159.2010.02924.x

Isolated tramadol overdose associated with brugada ECG pattern

Jon B. Cole, Srinivasan Sattiraju, Elisabeth F. Bilden, Richard W Asinger, Stefan C Bertog

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)

Original language	English (US)
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	35
Issue number	8
DOIs	https://doi.org/10.1111/j.1540-8159.2010.02924.x
State	Published - Aug 1 2012

Keywords

ECG pattern
brugada
sodium channel blockers
tramadol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1540-8159.2010.02924.x

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title = "Isolated tramadol overdose associated with brugada ECG pattern",

abstract = "Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)",

keywords = "ECG pattern, brugada, sodium channel blockers, tramadol",

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T1 - Isolated tramadol overdose associated with brugada ECG pattern

AU - Cole, Jon B.

AU - Sattiraju, Srinivasan

AU - Bilden, Elisabeth F.

AU - Asinger, Richard W

AU - Bertog, Stefan C

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)

AB - Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)

KW - ECG pattern

KW - brugada

KW - sodium channel blockers

KW - tramadol

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DO - 10.1111/j.1540-8159.2010.02924.x

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Isolated tramadol overdose associated with brugada ECG pattern

Abstract

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