Abstract
Melanoma is an aggressive cutaneous malignancy that can recur in the form of in-transit lesions. In-transit disease can present challenges for both physician and patient, particularly when unresectable and bulky. Multiple new therapeutic modalities have been introduced in recent time, but regional chemotherapy for extremity in-transit disease in theform of hyperthermic isolated limb perfusion and isolated limb infusion are useful tools in achieving disease response, improving survival in those that do not recur distantly, and helping to salvage limbs in cases where amputation is the only other treatment alternative. This chapter serves to cover the modern literature that guides current clinic practice using these modalities. While both are effective treatments, isolated limb infusion has gained momentum with increasing use due to its simplicity and similar disease response rates. With the introduction of new systemic agents, further research will need to look into the best ways that regional chemotherapy can be utilized within the scheme of a multimodality treatment plan for patients with in-transit extremity disease.
Original language | English (US) |
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Title of host publication | Cancer Regional Therapy |
Subtitle of host publication | HAI, HIPEC, HILP, ILI, PIPAC and Beyond |
Publisher | Springer International Publishing |
Pages | 379-394 |
Number of pages | 16 |
ISBN (Electronic) | 9783030288914 |
ISBN (Print) | 9783030288907 |
DOIs | |
State | Published - Jan 1 2019 |
Keywords
- Extremity
- HILP
- ILI
- In-transit disease
- Melanoma
- Metastatic melanoma
- Regional chemotherapy
- Unresectable