ISO: A critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection

Julie C. Baker-LePain, Robyn C Reed, Christopher V. Nicchitta

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Heat shock/chaperone protein (HSCP)-peptide complexes can access the cross-priming pathways of antigen presenting cells (APCs), and the gp96-associated peptides can be re-presented on APC MHC class I molecules to elicit CD8+ T cell activation. This immunological circuit is thought to provide the functional basis for HSCP function in tumor immunity. Recent findings identifying a 'natural adjuvant' function for HSCPs suggest complementary, or perhaps alternative, mechanisms of HSCP-mediated tumor rejection.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalCurrent Opinion in Immunology
Volume15
Issue number1
DOIs
StatePublished - Feb 2003

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