Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies

Timothy D. O'Brien; Robert A. Rizza; J. Aidan Carney; Peter C. Butler

doi:10.1210/jc.79.1.290

Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies

Timothy D. O'Brien
, Robert A. Rizza
, J. Aidan Carney
, Peter C. Butler

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic β-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.

Original language	English (US)
Pages (from-to)	290-292
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	79
Issue number	1
DOIs	https://doi.org/10.1210/jc.79.1.290
State	Published - Jul 1994

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title = "Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies",

abstract = "We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic β-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.",

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AU - Carney, J. Aidan

AU - Butler, Peter C.

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AB - We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic β-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.

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Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies

Abstract

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