TY - JOUR
T1 - Islet amyloid polypeptide (IAPP) does not inhibit glucose-stimulated insulin secretion from isolated perfused rat pancreas
AU - O'Brien, Timothy D.
AU - Westermark, Per
AU - Johnson, Kennth H.
PY - 1990/8/16
Y1 - 1990/8/16
N2 - Islet amyloid polypeptide (IAPP) is a recently discovered pancreatic islet hormone which is stored with insulin in the secretory vesicles of beta cells. Several lines of evidence suggested that IAPP might affect glucose-stimulated insulin secretion and, therefore, might play a role in the development of impaired insulin secretion which is typical of type 2 diabetes. In this study, the effects of human IAPP (amide) on glucose-stimulated insulin secretion was evaluated in the isolated perfused rat pancreas. IAPP in concetrations from 5 × 10-12 to 10-7 M had no significant effects on insulin secretion. IAPP, therefore, does not appear to be a significant modulator of glucose-stimulated insulin secretion at concentrations that are physiologically relevant.
AB - Islet amyloid polypeptide (IAPP) is a recently discovered pancreatic islet hormone which is stored with insulin in the secretory vesicles of beta cells. Several lines of evidence suggested that IAPP might affect glucose-stimulated insulin secretion and, therefore, might play a role in the development of impaired insulin secretion which is typical of type 2 diabetes. In this study, the effects of human IAPP (amide) on glucose-stimulated insulin secretion was evaluated in the isolated perfused rat pancreas. IAPP in concetrations from 5 × 10-12 to 10-7 M had no significant effects on insulin secretion. IAPP, therefore, does not appear to be a significant modulator of glucose-stimulated insulin secretion at concentrations that are physiologically relevant.
UR - http://www.scopus.com/inward/record.url?scp=0025148805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025148805&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(90)90524-Q
DO - 10.1016/0006-291X(90)90524-Q
M3 - Article
C2 - 2202297
AN - SCOPUS:0025148805
SN - 0006-291X
VL - 170
SP - 1223
EP - 1228
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -