Islet amyloid polypeptide (IAPP) does not inhibit glucose-stimulated insulin secretion from isolated perfused rat pancreas

Timothy D. O'Brien, Per Westermark, Kennth H. Johnson

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Islet amyloid polypeptide (IAPP) is a recently discovered pancreatic islet hormone which is stored with insulin in the secretory vesicles of beta cells. Several lines of evidence suggested that IAPP might affect glucose-stimulated insulin secretion and, therefore, might play a role in the development of impaired insulin secretion which is typical of type 2 diabetes. In this study, the effects of human IAPP (amide) on glucose-stimulated insulin secretion was evaluated in the isolated perfused rat pancreas. IAPP in concetrations from 5 × 10-12 to 10-7 M had no significant effects on insulin secretion. IAPP, therefore, does not appear to be a significant modulator of glucose-stimulated insulin secretion at concentrations that are physiologically relevant.

Original languageEnglish (US)
Pages (from-to)1223-1228
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume170
Issue number3
DOIs
StatePublished - Aug 16 1990

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