Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation?

B. J. Hering; D. Romann; A. Clarius; M. Brendel; R. G. Bretzel; K. Federlin

Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation?

Translated title of the contribution: Islands of Langerhans of cattle--potential donor tissue for clinical islet transplantation?

B. J. Hering
, D. Romann
, A. Clarius
, M. Brendel
, R. G. Bretzel
, K. Federlin

Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

A standard method for bovine islet isolation has been developed. The mean islet yield per gram pancreas obtained from the last twelve consecutive glands was 2,098 +/- 292 representing an insulin recovery of 36.1 +/- 6.5%. The static incubation of freshly isolated bovine islets in the presence of glucose resulted in a less distinct increase of insulin secretion than in the presence of free fatty acids. Nevertheless, xenotransplantation of bovine islets to immunosuppressed C57BL6J mice did reverse streptozotocin-induced diabetes for 2 to 6 days.

Translated title of the contribution	Islands of Langerhans of cattle--potential donor tissue for clinical islet transplantation?
Original language	German
Pages (from-to)	138-146
Number of pages	9
Journal	Zeitschrift für experimentelle Chirurgie, Transplantation, und künstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft für Chirurgie der DDR
Volume	22
Issue number	3
State	Published - 1989

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SDG 3 Good Health and Well-being

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Hering, B. J., Romann, D., Clarius, A., Brendel, M., Bretzel, R. G., & Federlin, K. (1989). Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation? Zeitschrift für experimentelle Chirurgie, Transplantation, und künstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft für Chirurgie der DDR, 22(3), 138-146.

Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation? / Hering, B. J.; Romann, D.; Clarius, A. et al.
In: Zeitschrift für experimentelle Chirurgie, Transplantation, und künstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft für Chirurgie der DDR, Vol. 22, No. 3, 1989, p. 138-146.

Research output: Contribution to journal › Article › peer-review

Hering, BJ, Romann, D, Clarius, A, Brendel, M, Bretzel, RG & Federlin, K 1989, 'Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation?', Zeitschrift für experimentelle Chirurgie, Transplantation, und künstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft für Chirurgie der DDR, vol. 22, no. 3, pp. 138-146.

@article{80209b0331a148b3966e2a67536e2935,

title = "Langerhans' sche Inseln des Rindes--potentielles Spendergewebe f{\"u}r die klinische Inseltransplantation?",

abstract = "A standard method for bovine islet isolation has been developed. The mean islet yield per gram pancreas obtained from the last twelve consecutive glands was 2,098 +/- 292 representing an insulin recovery of 36.1 +/- 6.5\%. The static incubation of freshly isolated bovine islets in the presence of glucose resulted in a less distinct increase of insulin secretion than in the presence of free fatty acids. Nevertheless, xenotransplantation of bovine islets to immunosuppressed C57BL6J mice did reverse streptozotocin-induced diabetes for 2 to 6 days.",

author = "Hering, \{B. J.\} and D. Romann and A. Clarius and M. Brendel and Bretzel, \{R. G.\} and K. Federlin",

year = "1989",

language = "German",

volume = "22",

pages = "138--146",

journal = "Zeitschrift f{\"u}r experimentelle Chirurgie, Transplantation, und k{\"u}nstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft f{\"u}r Chirurgie der DDR",

issn = "0232-7295",