Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation?

Translated title of the contribution: Islands of Langerhans of cattle--potential donor tissue for clinical islet transplantation?

B. J. Hering, D. Romann, A. Clarius, M. Brendel, R. G. Bretzel, K. Federlin

Research output: Contribution to journalArticlepeer-review

Abstract

A standard method for bovine islet isolation has been developed. The mean islet yield per gram pancreas obtained from the last twelve consecutive glands was 2,098 +/- 292 representing an insulin recovery of 36.1 +/- 6.5%. The static incubation of freshly isolated bovine islets in the presence of glucose resulted in a less distinct increase of insulin secretion than in the presence of free fatty acids. Nevertheless, xenotransplantation of bovine islets to immunosuppressed C57BL6J mice did reverse streptozotocin-induced diabetes for 2 to 6 days.

Translated title of the contributionIslands of Langerhans of cattle--potential donor tissue for clinical islet transplantation?
Original languageGerman
Pages (from-to)138-146
Number of pages9
JournalZeitschrift für experimentelle Chirurgie, Transplantation, und künstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft für Chirurgie der DDR
Volume22
Issue number3
StatePublished - 1989

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