Is vascular stiffness a target for therapy?

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Early cardiovascular disease starts in the endothelium leading to functional changes in the vasculature. These changes can be depicted by assessment of arterial stiffness or elasticity. There are several techniques to assess arterial stiffness. Increased arterial stiffness or decreased arterial elasticity has been associated with cardiovascular risk factors. There is now evidence that small artery elasticity is a strong predictor for arterial hypertension. Moreover arterial elasticity provides extra prognostic information beyond arterial blood pressure measurement. Arterial stiffness attenuation may reflect the true reduction of arterial wall damage. Results: ACE-inhibitors, angiotensin II receptor blockers, aldosterone antagonists and calcium antagonists have favorable effects in improving arterial elasticity, while betablockers have an inverse effect. Diuretics have not been evaluated. Lipid lowering therapy, some antidiabetic therapy have shown to reduce arterial stiffness. Inflammatory and infectious diseases have been associated with vascular inflammation and consequently increase in arterial stiffness. The effect of anti-inflammatory agents and antiretroviral therapy on arterial stiffness is under investigation. Conclusions: Measurement of arterial stiffness will not only be helpful in the detection of early vascular disease but also as a tool in the selection and follow-up monitoring of therapeutic strategies aimed at preventing or delaying progression of vascular disease.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalCardiovascular Drugs and Therapy
Issue number4
StatePublished - Aug 2010


  • Arterial elasticity
  • Arterial stiffness
  • Cardiovascular disease
  • Hypertension
  • Prevention
  • Vascular therapy


Dive into the research topics of 'Is vascular stiffness a target for therapy?'. Together they form a unique fingerprint.

Cite this