Abstract
Background: While ulcerative colitis (UC) is a risk factor for colorectal cancer, the association of UC with survival after colorectal cancer has not been studied in an older population. Aims: The objective of our study was to compare the survival of colorectal cancer between persons with and without UC. Methods: All cases of colorectal cancer (CRC) in persons 67 and older residing in a SEER catchment area and enrolled in the Medicare between 1993 and 1999 were assessed. We identified diagnosis of UC using ICD-9 codes on Medicare outpatient, office, and inpatient claims in the 2 years prior to the date of diagnosis. We used Cox proportional hazards model and Kaplan-Meier curves to compare survival between individuals with UC and CRC (UC-CRC) and sporadic CRC Results: We identified 47,543 cases of colorectal cancer. Cases with UC-CRC tend to be diagnosed at earlier stages compared to sporadic CRC (42 vs. 37% local (TNM stage 1 and 2) and 11 vs. 17% distant spread (TNM stage 4), respectively; P value = 0.04). Controlling for age, gender, race and stage, diagnosis of UC did not affect the 3-year survival for CRC Conclusions: Colorectal cancers tend to be diagnosed at earlier stages among persons with UC, but there is no difference in 3-year survival rates for colorectal cancer among individuals with and without UC.
Original language | English (US) |
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Pages (from-to) | 1647-1651 |
Number of pages | 5 |
Journal | Digestive Diseases and Sciences |
Volume | 57 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2012 |
Bibliographical note
Funding Information:Acknowledgment Supported by VA Career Development Award (CDA-2) (A.S).
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
Keywords
- Colorectal cancer
- SEER-Medicare
- Survival
- Ulcerative colitis