Is ulcerative colitis associated with survival among older persons with colorectal cancer in the us? A population-based case-control study

Aasma Shaukat, Nadim I. Salfiti, Daniel J. Virnig, David H. Howard, Shanthi V. Sitaraman, Jonathan M. Liff, Frank A. Lederle

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: While ulcerative colitis (UC) is a risk factor for colorectal cancer, the association of UC with survival after colorectal cancer has not been studied in an older population. Aims: The objective of our study was to compare the survival of colorectal cancer between persons with and without UC. Methods: All cases of colorectal cancer (CRC) in persons 67 and older residing in a SEER catchment area and enrolled in the Medicare between 1993 and 1999 were assessed. We identified diagnosis of UC using ICD-9 codes on Medicare outpatient, office, and inpatient claims in the 2 years prior to the date of diagnosis. We used Cox proportional hazards model and Kaplan-Meier curves to compare survival between individuals with UC and CRC (UC-CRC) and sporadic CRC Results: We identified 47,543 cases of colorectal cancer. Cases with UC-CRC tend to be diagnosed at earlier stages compared to sporadic CRC (42 vs. 37% local (TNM stage 1 and 2) and 11 vs. 17% distant spread (TNM stage 4), respectively; P value = 0.04). Controlling for age, gender, race and stage, diagnosis of UC did not affect the 3-year survival for CRC Conclusions: Colorectal cancers tend to be diagnosed at earlier stages among persons with UC, but there is no difference in 3-year survival rates for colorectal cancer among individuals with and without UC.

Original languageEnglish (US)
Pages (from-to)1647-1651
Number of pages5
JournalDigestive Diseases and Sciences
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • Colorectal cancer
  • SEER-Medicare
  • Survival
  • Ulcerative colitis

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