Is there a common neuroanatomical substrate of language deficit between autism spectrum disorder and specific language impairment?

Judith S. Verhoeven, Nathalie Rommel, Elena Prodi, Alexander Leemans, Inge Zink, Ellen Vandewalle, Ilse Noens, Johan Wagemans, Jean Steyaert, Bart Boets, Ann Van de Winckel, Paul De Cock, Lieven Lagae, Stefan Sunaert

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Discussion of an overlap between specific language impairment (SLI) and autism spectrum disorder (ASD) is on going. The most intriguing overlap between both phenotypes is the similarity in the observed language deficits described in SLI and a subgroup of ASD with co-occurring linguistic impairment, ASD-LI. Examining whether a similar neuroanatomical substrate underlies this phenotypical linguistic overlap, we studied the white matter microstructural properties of the superior longitudinal fascicle (SLF) of 19 ASD-LI adolescents (mean age 13.8 ± 1.6 years) and 21 age-matched controls and compared them with 13 SLI children (mean age 10.1 ± 0.4 years) and 12 age-matched controls. A linguistic profile assessment and a diffusion tensor imaging analysis of the SLF were performed. Linguistic testing revealed a mixed receptive-expressive disorder profile in both groups, confirming their overlap at phenotypical level. At neuroanatomical level, no significant differences in mean SLF fractional anisotropy (FA) and mean SLF apparent diffusion coefficient values between ASD-LI participants and controls were seen. By contrast, the mean SLF FA was significantly reduced in the SLI children as compared with their controls. The observation of structural SLF disturbances in SLI but not in ASD-LI suggests the existence of a different neuroanatomical substrate for the language deficits in both disorders.

Original languageEnglish (US)
Pages (from-to)2263-2271
Number of pages9
JournalCerebral Cortex
Volume22
Issue number10
DOIs
StatePublished - Oct 2012

Bibliographical note

Funding Information:
‘‘Fund for Scientific Research-Flanders,’’ FWO, Belgium (G.0354.06); IUAP-KUL (FWO fellowship asp/07 to J.S.V.); the Research Council (IDO/08/013).

Keywords

  • autism spectrum disorder
  • diffusion tensor imaging
  • specific language impairment
  • superior longitudinal fascicle

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