Is the bis(μ-oxo)dicopper core capable of hydroxylating an arene?

Patrick L. Holland, Kenton R. Rodgers, William B. Tolman

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

Direct attack of the bis(μ-oxo)dicopper core on an arene appears feasible in tyrosinase and model complexes on the basis of studies of new [Cu(III)/2(μ-O)2]2+ compounds supported by bidentate imine/amine ligands. In the first demonstration of such reactivity for a bis(μ- uxo)dicopper core, decomposition of these intermediates caused hydroxylation of a pendant phenyl ring [Eq. (a) in a reaction analogous to that catalyzed by tyrosinase.

Original languageEnglish (US)
Pages (from-to)1139-1142
Number of pages4
JournalAngewandte Chemie - International Edition
Volume38
Issue number8
DOIs
StatePublished - Apr 19 1999

Keywords

  • Copper
  • Hydroxylations
  • Monooxygenases
  • Oxidases
  • Tyrosinase

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