Is hypercholesterolemia a risk factor for Alzheimer's disease?

W. Gibson Wood, Urule Igbavboa, Gunter P. Eckert, Leslie N. Johnson-Anuna, Walter E. Müller

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


There is considerable attention being given to the association of Alzheimer's disease and cholesterol homeostasis. To that end, some have suggested that elevated cholesterol levels are a risk factor for Alzheimer's disease. If elevated cholesterol is a risk factor for Alzheimer's disease, then it would be expected that patients with Alzheimer's disease would have elevated serum and brain cholesterol levels. Studies were reviewed that have examined cholesterol levels in Alzheimer's patients and control subjects, including prospective studies, and based on that review, the conclusion is reached that the majority of studies do not support elevated cholesterol levels in serum and brain as a risk factor for Alzheimer's disease. Alternative hypotheses are discussed, including cholesterol domains and subgroups of individuals with hypercholesteremia.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalMolecular neurobiology
Issue number1-3
StatePublished - Feb 2005

Bibliographical note

Funding Information:
This work was supported by NIH grants AG23524, AG-18357, NATO Collaborative Linkage grant 980136, and the Medical Research Program of the Department of Veterans Affairs.


  • Alzheimer's disease
  • Amyloid β-protein
  • Apolipoprotein E, cholesterol
  • Lipoproteins
  • Statins


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