TY - JOUR
T1 - Is high mole count a marker of more than melanoma risk? Eczema diagnosis is associated with melanocytic nevi in children
AU - Dellavalle, Robert P.
AU - Hester, Eric J.
AU - Stegner, Deborah L.
AU - Deas, Ann M.
AU - Pacheco, Theresa R.
AU - Mokrohisky, Stefan
AU - Morelli, Joseph G.
AU - Crane, Lori A.
PY - 2004/5
Y1 - 2004/5
N2 - Background: The number of melanocytic nevi is the best single marker of increased melanoma risk. In a previous study, adults with severe eczema were reported to have significantly fewer nevi than adults without eczema. Observations: In a nested case-control design within a randomized, controlled interventional trial of additional sun protection vs standard care in 269 children, a history of eczema was reported by the parents of 44 (16%) of the children. More nevi were found in children with a parental report of previous eczema diagnosis than in children without reported eczema (median, 7.5 nevi vs 5.0 nevi; P=.01). Eczema diagnosis was most significantly associated with more melanocytic nevi in children with lightly pigmented skin (8.5 nevi vs 6.0 nevi; P<.001). In multivariate logistical regression analysis, including assessment of hair color, sun protection practices, and study assignment (intervention vs standard care), eczema status remained significantly predictive of nevi number in children (P<.001). Conclusions: In contrast to a previous study that associated severe eczema with fewer nevi in adults, in the present study children with a reported history of eczema had more nevi than children without a reported history of eczema.
AB - Background: The number of melanocytic nevi is the best single marker of increased melanoma risk. In a previous study, adults with severe eczema were reported to have significantly fewer nevi than adults without eczema. Observations: In a nested case-control design within a randomized, controlled interventional trial of additional sun protection vs standard care in 269 children, a history of eczema was reported by the parents of 44 (16%) of the children. More nevi were found in children with a parental report of previous eczema diagnosis than in children without reported eczema (median, 7.5 nevi vs 5.0 nevi; P=.01). Eczema diagnosis was most significantly associated with more melanocytic nevi in children with lightly pigmented skin (8.5 nevi vs 6.0 nevi; P<.001). In multivariate logistical regression analysis, including assessment of hair color, sun protection practices, and study assignment (intervention vs standard care), eczema status remained significantly predictive of nevi number in children (P<.001). Conclusions: In contrast to a previous study that associated severe eczema with fewer nevi in adults, in the present study children with a reported history of eczema had more nevi than children without a reported history of eczema.
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U2 - 10.1001/archderm.140.5.577
DO - 10.1001/archderm.140.5.577
M3 - Article
C2 - 15148102
AN - SCOPUS:2442714100
SN - 0003-987X
VL - 140
SP - 577
EP - 580
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 5
ER -