Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water

Margaret E. Olson; James P. Carolan; Michael V. Chiodo; Phillip R. Lazzara; Ram S. Mohan

doi:10.1016/j.tetlet.2010.05.112

Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water

Margaret E. Olson
, James P. Carolan
, Michael V. Chiodo
, Phillip R. Lazzara
, Ram S. Mohan

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0-5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.

Original language	English (US)
Pages (from-to)	3969-3971
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2010.05.112
State	Published - Jul 28 2010
Externally published	Yes

Bibliographical note

Funding Information:
The authors gratefully acknowledge the funding from the National Science Foundation for a RUI (Research in Undergraduate Institutions) Grant ( # 0650682 ) awarded to R.S.M.

Keywords

Acetals
Deprotection
Iron(III) tosylate
Water

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10.1016/j.tetlet.2010.05.112

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title = "Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water",

abstract = "The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0-5.0 mol \%). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.",

keywords = "Acetals, Deprotection, Iron(III) tosylate, Water",

author = "Olson, \{Margaret E.\} and Carolan, \{James P.\} and Chiodo, \{Michael V.\} and Lazzara, \{Phillip R.\} and Mohan, \{Ram S.\}",

note = "Funding Information: The authors gratefully acknowledge the funding from the National Science Foundation for a RUI (Research in Undergraduate Institutions) Grant ( \# 0650682 ) awarded to R.S.M. ",

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language = "English (US)",

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T1 - Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water

AU - Olson, Margaret E.

AU - Carolan, James P.

AU - Chiodo, Michael V.

AU - Lazzara, Phillip R.

AU - Mohan, Ram S.

N1 - Funding Information: The authors gratefully acknowledge the funding from the National Science Foundation for a RUI (Research in Undergraduate Institutions) Grant ( # 0650682 ) awarded to R.S.M.

PY - 2010/7/28

Y1 - 2010/7/28

N2 - The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0-5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.

AB - The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0-5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.

KW - Acetals

KW - Deprotection

KW - Iron(III) tosylate

KW - Water

UR - https://www.scopus.com/pages/publications/77953687724

UR - https://www.scopus.com/pages/publications/77953687724#tab=citedBy

U2 - 10.1016/j.tetlet.2010.05.112

DO - 10.1016/j.tetlet.2010.05.112

M3 - Article

AN - SCOPUS:77953687724

SN - 0040-4039

VL - 51

SP - 3969

EP - 3971

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water

Abstract

Bibliographical note

Keywords

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