Iron(III) tosylate-catalyzed deprotection of aromatic acetals in water

Margaret E. Olson, James P. Carolan, Michael V. Chiodo, Phillip R. Lazzara, Ram S. Mohan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0-5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benign solvent, makes this procedure especially attractive for acetal deprotection.

Original languageEnglish (US)
Pages (from-to)3969-3971
Number of pages3
JournalTetrahedron Letters
Issue number30
StatePublished - Jul 28 2010
Externally publishedYes

Bibliographical note

Funding Information:
The authors gratefully acknowledge the funding from the National Science Foundation for a RUI (Research in Undergraduate Institutions) Grant ( # 0650682 ) awarded to R.S.M.


  • Acetals
  • Deprotection
  • Iron(III) tosylate
  • Water


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