Iron Oxide Nanospheres and Nanocubes for Magnetic Hyperthermia Therapy: A Comparative Study

Z. Nemati, R. Das, J. Alonso, E. Clements, M. H. Phan, H. Srikanth

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Improving the heating capacity of magnetic nanoparticles (MNPs) for hyperthermia therapy is an important but challenging task. Through a comparative study of the inductive heating properties of spherical and cubic Fe3O4 MNPs with two distinct average volumes (∼7000 nm3 and 80,000 nm3), we demonstrate that, for small size (∼7000 nm3), the cubic MNPs heat better compared with the spherical MNPs. However, the opposite trend is observed for larger size (∼80,000 nm3). The improvement in heating efficiency in cubic small-sized MNPs (∼7000 nm3) can be attributed to enhanced anisotropy and the formation of chain-like aggregates, whereas the decrease of the heating efficiency in cubic large-sized MNPs (∼80,000 nm3) has been attributed to stronger aggregation of particles. Physical motion is shown to contribute more to the heating efficiency in case of spherical than cubic MNPs, when dispersed in water. These findings are of crucial importance in understanding the role of shape anisotropy and optimizing the heating response of magnetic nano-structures for advanced hyperthermia.

Original languageEnglish (US)
Pages (from-to)3764-3769
Number of pages6
JournalJournal of Electronic Materials
Issue number6
StatePublished - Jun 1 2017

Bibliographical note

Funding Information:
Work was partially supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award # DE-FG02-07ER46438. H.S. acknowledges support from the Bizkaia Talent Program, Basque Country (Spain). J.A. acknowledges the financial support provided through a postdoctoral fellowship from the Basque Government.

Publisher Copyright:
© 2017, The Minerals, Metals & Materials Society.


  • Iron oxide nanoparticles
  • biomedical applications
  • heating efficiency
  • magnetic hyperthermia


Dive into the research topics of 'Iron Oxide Nanospheres and Nanocubes for Magnetic Hyperthermia Therapy: A Comparative Study'. Together they form a unique fingerprint.

Cite this