Iron Overload in Survivors of Childhood Cancer

Ashley Schempp, Jill Lee, Susan Kearney, Daniel A. Mulrooney, Angela R. Smith

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Iron overload is a significant cause of morbidity and mortality for patients who require frequent transfusions. We completed a prospective, cross-sectional study to evaluate the prevalence of iron overload in previously transfused childhood cancer survivors. Survivors recruited from the University of Minnesota Long-Term Follow-Up Clinic were stratified into 3 groups: oncology patients not treated with hematopoietic stem cell transplantation (HSCT) (n=27), patients treated with allogeneic HSCT (n=27), and patients treated with autologous HSCT (n=9). Serum ferritin was collected and hepatic magnetic resonance imaging (FerriScan) was obtained for those with iron overload (defined as ferritin ≥ 1000 ng/mL). The prevalence of iron overload in subjects with a history of allogeneic HSCT was 25.9% (95% CI, 9.4%-42.5%) compared with only 3.7% (95% CI, 0%-10.8%) in subjects treated without HSCT and 0% in subjects treated with autologous HSCT. No association was found between serum ferritin levels and the presence of cardiac, liver, or endocrine dysfunction. The prevalence of iron overload in subjects who received no HSCT or autologous HSCT is low in our study. A higher prevalence was found in patients receiving allogeneic HSCT, reiterating the importance of screening these patients for iron overload in accordance with the current Children's Oncology Group Long Term Follow-Up Guidelines.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved.


  • Ferritin
  • Iron overload
  • Survivorship

PubMed: MeSH publication types

  • Journal Article


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